Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis.
Identifieur interne : 002978 ( Main/Exploration ); précédent : 002977; suivant : 002979Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis.
Auteurs : Mahyar Etminan [Canada] ; Sudeep S. Gill ; Ali SamiiSource :
- The Lancet. Neurology [ 1474-4422 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Ascorbic Acid, Carotenoids, Vitamin E, beta Carotene.
- diet therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- prevention & control : Parkinson Disease.
- Humans, Risk Factors.
Abstract
We studied the effect of vitamin C, vitamin E, and beta carotene intake on the risk of Parkinson's disease (PD). We did a systematic review and meta-analysis of observational studies published between 1966 and March 2005 searching MEDLINE, EMBASE, and the Cochrane Library. Eight studies were identified (six case-control, one cohort, and one cross-sectional). We found that dietary intake of vitamin E protects against PD. This protective influence was seen with both moderate intake (relative risk 0.81, 95% CI 0.67-0.98) and high intake (0.78, 0.57-1.06) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or beta carotene. We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.
DOI: 10.1016/S1474-4422(05)70097-1
PubMed: 15907740
Affiliations:
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Le document en format XML
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Gill</name></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></author></analytic><series><title level="j">The Lancet. Neurology</title><idno type="ISSN">1474-4422</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ascorbic Acid (therapeutic use)</term><term>Carotenoids (therapeutic use)</term><term>Humans</term><term>Parkinson Disease (diet therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (prevention & control)</term><term>Risk Factors</term><term>Vitamin E (therapeutic use)</term><term>beta Carotene (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ascorbic Acid</term><term>Carotenoids</term><term>Vitamin E</term><term>beta Carotene</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the effect of vitamin C, vitamin E, and beta carotene intake on the risk of Parkinson's disease (PD). We did a systematic review and meta-analysis of observational studies published between 1966 and March 2005 searching MEDLINE, EMBASE, and the Cochrane Library. Eight studies were identified (six case-control, one cohort, and one cross-sectional). We found that dietary intake of vitamin E protects against PD. This protective influence was seen with both moderate intake (relative risk 0.81, 95% CI 0.67-0.98) and high intake (0.78, 0.57-1.06) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or beta carotene. We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Gill, Sudeep S" sort="Gill, Sudeep S" uniqKey="Gill S" first="Sudeep S" last="Gill">Sudeep S. Gill</name><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name></noCountry><country name="Canada"><noRegion><name sortKey="Etminan, Mahyar" sort="Etminan, Mahyar" uniqKey="Etminan M" first="Mahyar" last="Etminan">Mahyar Etminan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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